产品名 | 产品编码 | 产品包装 (DMSO溶液/10mM) |
免疫活性化合物库Target Probe+ | LA-1008 | 96孔板: 10 μL/well, 20 μL/well, 或100 μL/well |
“免疫”是人体极其重要的自卫功能。人体依靠自身的免疫力,能抵御种类庞大的的各种疾病。天然产物中多种活性物质具有免疫活性,如多酚类、黄酮类、含氮杂环类化合物等。
产品名 | 产品编码 | 产品包装 (DMSO溶液/10mM) |
免疫活性化合物库Target Probe+ | LA-1008 | 96孔板: 10 μL/well, 20 μL/well, 或100 μL/well |
“免疫”是人体极其重要的自卫功能。人体依靠自身的免疫力,能抵御种类庞大的的各种疾病。天然产物中多种活性物质具有免疫活性,如多酚类、黄酮类、含氮杂环类化合物等。
图1 免疫类活性化合物已知相关疾病领域
表2 免疫类活性化合物已知药物靶点示例
Xanthine dehydrogenase | Carbonic anhydrase | Cytochrome P450 1B1/1A2/1A1/19A1 | Arachidonate 5-lipoxygenase |
Microtubule-associated protein tau | Aldehyde dehydrogenase | Estrogen receptor alpha/beta | Muscleblind-like protein 1/2/3 |
5-hydroxytryptamine receptor 1A/1B/2A/2B/2C (by homology) | Beta amyloid A4 protein | Tyrosyl-DNA phosphodiesterase 1 | Androgen receptor |
cGMP-specific 3',5'-cyclic phosphodiesterase | Glucocorticoid receptor | Epidermis-type lipoxygenase 3 (by homology) | ATP-binding cassette sub-family G member 2 |
P-glycoprotein 1 | Vascular endothelial growth factor receptor 1/2/3 (by homology) | Platelet-derived growth factor receptor alpha/beta | Adenosine receptor A1 (by homology) |
Fibroblast growth factor receptor 1/2/3/4 | Caspase-3 subunit p12 | Caspase-7 subunit p20 (by homology) | Caspase-6 subunit p18 (by homology) |
Neutrophil elastase | Azurocidin (by homology) | Myeloblastin (by homology) | Quinone oxidoreductase (by homology) |
Mitogen-activated protein kinase 8/9/10 (by homology) | Mineralocorticoid receptor (by homology) | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (by homology) |
Arachidonate 15-lipoxygenase B | |||
绿色:与原天然产物的靶点相同;黑色:新靶点 |