免疫活性化合物库 Target Probe+
免疫活性化合物库 Target Probe+
产品名 产品编码 分子库数量 产品包装 (DMSO溶液/10mM)
免疫活性化合物库Target Probe+ LA-1008 免疫化合物分子75个
M 系列131个
C系列167个
96孔板:
10 μL/well, 20 μL/well, 或100 μL/well

 

      “免疫”是人体极其重要的自卫功能。人体依靠自身的免疫力,能抵御种类庞大的的各种疾病。天然产物中多种活性物质具有免疫活性,如多酚类、黄酮类、含氮杂环类化合物等。

       该库收集了75个免疫类化合物,对其进行M+C系列改造成潜在的新的活性分子(已改造~300个),可以广泛地应用于高通量筛选 (HTS) 和高内涵筛选 (HCS),为优化药物结构提供了重要的线索;同时继续提供定制的P系列分子。

图1 免疫类活性化合物已知相关疾病领域

 

 

 

 

表2 免疫类活性化合物已知药物靶点示例

 

 

Xanthine dehydrogenase Carbonic anhydrase  Cytochrome P450 1B1/1A2/1A1/19A1 Arachidonate 5-lipoxygenase
Microtubule-associated protein tau Aldehyde dehydrogenase  Estrogen receptor alpha/beta Muscleblind-like protein 1/2/3
5-hydroxytryptamine receptor 1A/1B/2A/2B/2C (by homology) Beta amyloid A4 protein Tyrosyl-DNA phosphodiesterase 1 Androgen receptor 
cGMP-specific 3',5'-cyclic phosphodiesterase Glucocorticoid receptor  Epidermis-type lipoxygenase 3 (by homology) ATP-binding cassette sub-family G member 2
P-glycoprotein 1 Vascular endothelial growth factor receptor 1/2/3 (by homology) Platelet-derived growth factor receptor alpha/beta Adenosine receptor A1 (by homology)
Fibroblast growth factor receptor 1/2/3/4 Caspase-3 subunit p12 Caspase-7 subunit p20 (by homology) Caspase-6 subunit p18 (by homology)
Neutrophil elastase Azurocidin (by homology) Myeloblastin (by homology) Quinone oxidoreductase (by homology)
Mitogen-activated protein kinase 8/9/10 (by homology) Mineralocorticoid receptor (by homology) 3-hydroxy-3-methylglutaryl-coenzyme A reductase Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (by homology)
Arachidonate 15-lipoxygenase B      
绿色:与原天然产物的靶点相同;黑色:新靶点

 

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