产品名 | 产品编码 | 产品包装 (DMSO溶液/10mM) |
多酚类活性化合物库 Target Probe+ | LA-1002 | 96孔板: 10 μL/well, 20 μL/well, 或100 μL/well |
多酚类化合物主要指一类由两个及以上羟基(-OH)或甲氧基(-OMe)直接与芳香烃基团结合而成的天然产物,广泛存在于植物体内,具有强抗氧化性、抑菌抑酶特性、抗肿瘤等多功效的天然产物,主要的结构包括黄酮类、醌类、生物碱类、苯丙素类以及其它多酚类。
产品名 | 产品编码 | 产品包装 (DMSO溶液/10mM) |
多酚类活性化合物库 Target Probe+ | LA-1002 | 96孔板: 10 μL/well, 20 μL/well, 或100 μL/well |
多酚类化合物主要指一类由两个及以上羟基(-OH)或甲氧基(-OMe)直接与芳香烃基团结合而成的天然产物,广泛存在于植物体内,具有强抗氧化性、抑菌抑酶特性、抗肿瘤等多功效的天然产物,主要的结构包括黄酮类、醌类、生物碱类、苯丙素类以及其它多酚类。
图 1 多酚类活性化合物已知相关疾病领域
表2 多酚类活性化合物药物靶点示例
Microtubule-associated protein tau | Cytochrome P450 1B1/19A1 | Aldo-keto reductase family 1 member B15/B10 (by homology) | Xanthine dehydrogenase |
Carbonic anhydrase | Estrogen receptor | Nitric oxide synthase | Tyrosyl-DNA phosphodiesterase 1 |
Arachidonate 5-lipoxygenase | Aldose reductase (by homology) | Epidermal growth factor receptor erbB1 | Cyclooxygenase 2 |
Cannabinoid receptor 2 | Adenosine A1 receptor (by homology) | Quinone reductase 2 | Dual specificity mitogen-activated protein kinase 1 |
P-glycoprotein 1 | Multidrug resistance-associated protein 1 | 5-hydroxytryptamine receptor 1A/1B | Epidermis-type lipoxygenase 3 (by homology) |
Quinone oxidoreductase (by homology) | ATP-binding cassette sub-family G member 2 | Caspase-3 subunit p12 | Caspase-7 subunit p20 (by homology) |
Caspase-6 subunit p18 (by homology) | Sodium/myo-inositol cotransporter (by homology) | Sodium/glucose cotransporter 4/5 | Mitochondrial |
Plasmin light chain B | Apolipoprotein(a) (by homology) | Prostaglandin G/H synthase 1/2 (by homology) | Serine/threonine-protein kinase/endoribonuclease IRE1 |
Beta amyloid A4 protein; ATP-binding cassette sub-family G member 2 | Cyclooxygenase 1 | Sodium/glucose cotransporter 1/2 | Aldehyde dehydrogenase |
Solute carrier family 28 member 3 | Arachidonate 15-lipoxygenase B | Interleukin-2 | Low affinity sodium-glucose cotransporter |
Inosine-5'-monophosphate dehydrogenase | Cell division control protein 42 homolog | Ras-related C3 botulinum toxin substrate 1 | Epoxide hydratase |
Adenosine A3 receptor | Phosphodiesterase 5A | Neutrophil elastase | Azurocidin (by homology) |
Myeloblastin (by homology) | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 | Cytosolic 10-formyltetrahydrofolate dehydrogenase | Retinal dehydrogenase 1/2 |
Amine oxidase [flavin-containing] A/B | NADPH oxidase 4 | Estradiol 17-beta-dehydrogenase 2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 (by homology) |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Muscleblind-like protein | Canalicular multispecific organic anion transporter 2 (by homology) | FAD-linked sulfhydryl oxidase ALR |
绿色:与原天然产物的靶点相同;黑色:新靶点 |