| 产品名 | 产品编码 | 分子库数量 | 产品包装 （DMSO溶液/10mM） |
| 多酚类活性化合物库 Target Probe+ | LA-1002 | 多酚类活性分子198个 M 系列 427个 C系列522个 |
96孔板： 10 μL/well, 20 μL/well, 或100 μL/well |
多酚类化合物主要指一类由两个及以上羟基（-OH）或甲氧基（-OMe）直接与芳香烃基团结合而成的天然产物，广泛存在于植物体内，具有强抗氧化性、抑菌抑酶特性、抗肿瘤等多功效的天然产物，主要的结构包括黄酮类、醌类、生物碱类、苯丙素类以及其它多酚类。
该库目前包括多酚类天然产物198个，涵盖了市场上大部分用于药物筛选的多酚类天然产物，后衍生修饰后的M+C系列的已达到～950个。本库的仍在持续增加，为药物筛选提供全新的多样化的筛选工具。
图 1 多酚类活性化合物已知相关疾病领域
表2 多酚类活性化合物药物靶点示例
| Microtubule-associated protein tau | Cytochrome P450 1B1/19A1 | Aldo-keto reductase family 1 member B15/B10 (by homology) | Xanthine dehydrogenase |
| Carbonic anhydrase | Estrogen receptor | Nitric oxide synthase | Tyrosyl-DNA phosphodiesterase 1 |
| Arachidonate 5-lipoxygenase | Aldose reductase (by homology) | Epidermal growth factor receptor erbB1 | Cyclooxygenase 2 |
| Cannabinoid receptor 2 | Adenosine A1 receptor (by homology) | Quinone reductase 2 | Dual specificity mitogen-activated protein kinase 1 |
| P-glycoprotein 1 | Multidrug resistance-associated protein 1 | 5-hydroxytryptamine receptor 1A/1B | Epidermis-type lipoxygenase 3 (by homology) |
| Quinone oxidoreductase (by homology) | ATP-binding cassette sub-family G member 2 | Caspase-3 subunit p12 | Caspase-7 subunit p20 (by homology) |
| Caspase-6 subunit p18 (by homology) | Sodium/myo-inositol cotransporter (by homology） | Sodium/glucose cotransporter 4/5 | Mitochondrial |
| Plasmin light chain B | Apolipoprotein(a) (by homology) | Prostaglandin G/H synthase 1/2 (by homology) | Serine/threonine-protein kinase/endoribonuclease IRE1 |
| Beta amyloid A4 protein; ATP-binding cassette sub-family G member 2 | Cyclooxygenase 1 | Sodium/glucose cotransporter 1/2 | Aldehyde dehydrogenase |
| Solute carrier family 28 member 3 | Arachidonate 15-lipoxygenase B | Interleukin-2 | Low affinity sodium-glucose cotransporter |
| Inosine-5'-monophosphate dehydrogenase | Cell division control protein 42 homolog | Ras-related C3 botulinum toxin substrate 1 | Epoxide hydratase |
| Adenosine A3 receptor | Phosphodiesterase 5A | Neutrophil elastase | Azurocidin (by homology) |
| Myeloblastin (by homology) | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 | Cytosolic 10-formyltetrahydrofolate dehydrogenase | Retinal dehydrogenase 1/2 |
| Amine oxidase [flavin-containing] A/B | NADPH oxidase 4 | Estradiol 17-beta-dehydrogenase 2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 (by homology) |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Muscleblind-like protein | Canalicular multispecific organic anion transporter 2 (by homology) | FAD-linked sulfhydryl oxidase ALR |
| 绿色：与原天然产物的靶点相同；黑色：新靶点 | |||
